TRANSPORT MECHANISMS OF MONOCARBOXYLIC ACID DRUGS THROUGH THE LIPID BILAYER

Monocarboxylic acid transport.

Monocarboxylates such as lactate, pyruvate, and the ketone bodies play major roles in metabolism and must be transported across both the plasma membrane and mitochondrial inner membrane. A family of five proton-linked MonoCarboxylate Transporters (MCTs) is involved in the former and the mitochondrial pyruvate carrier (MPC) mediates the latter. In the intestine and kidney, two Sodium-coupled Mon...

Boronic Acids Selectively Facilitate Glucose Transport through a Lipid Bilayer'

Glucose is the most important carbohydrate in human metabolism. Many body tissues depend on glucose as a primary source of energy. To ensure that a sufficient supply is always available, the blood glucose concentration is maintained around 5 mM. In addition, the tissues retain an abundance of glucose transporters to facilitate glucose movement across the cell membranes.' The transporters are in...

Boronic acid mediated ion transport through bilayer membranes

Chloride Transport in Porous Lipid Bilayer Membranes

This paper describes dissipative Cl(-) transport in "porous" lipid bilayer membranes, i.e., cholesterol-containing membranes exposed to 1-3 x 10(-7) M amphotericin B. P(DCl) (cm.s(-1)), the diffusional permeability coefficient for Cl(-), estimated from unidirectional (36)Cl(-) fluxes at zero volume flow, varied linearly with the membrane conductance (Gm, ohm(-1).cm(-2)) when the contributions o...

Non-involvement of the human monocarboxylic acid transporter 1 (MCT1) in the transport of phenolic acid.

Phenolic acids such as p-coumaric acid and microbial metabolites of poorly absorbed polyphenols are absorbed by the monocarboxylic acid transporter (MCT)-mediated transport system which is identical to the fluorescein/H(+) cotransport system. We focus here on the physiological impact of MCT-mediated absorption and distribution. We examined whether MCT1, the best-characterized isoform found in a...